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Best Pain Relief for Knee Pain: Top Treatments that Work

June 13, 2025

A plus-size African American woman in a yellow shirt and glasses is sitting on her bed in her bedroom, feeling pain in her left knee.

Knee pain, especially when it lingers, can be more than just a nuisance—it can take over your life if you let it. One day, you are strolling through the park; the next, you are calculating the shortest route to the kitchen to avoid that familiar twinge. It can creep in or hit you all at once, but either way, it can make even simple movements feel like uphill battles.

But here is the good news: you are not powerless against knee pain. You can find safe, tried-and-true treatments that target it at its root, not just mask it. From cutting-edge procedures to all-natural, regenerative therapies, you now have more effective and low-risk choices than ever before.

Below, we have put together a short list of the most effective non-drug, nonsurgical treatments for knee pain available today.

 

Viscosupplementation: An Underrated Solution to Knee Pain

Viscosupplementation, also known as knee gel injections, might not be the first treatment that comes to mind, but it deserves a place on your radar, especially if you have osteoarthritis.

This treatment involves injecting hyaluronic acid, a substance naturally found in joint fluid, directly into your knee to replenish lost lubrication. Think of viscosupplementation as giving your knee a fresh set of shock absorbers to ease friction and help it move more freely and comfortably.

Though viscosupplementation does not reverse joint damage or cure arthritis, it yields promising results. Many patients experience remarkable improvements in their pain levels, mobility, and overall quality of life following the treatment. While results vary, it can be a great option for those looking to delay surgery for as long as possible.

 

Platelet-Rich Plasma (PRP) Therapy: Using Your Body to Heal Itself

Platelet-rich plasma (PRP) therapy is gaining traction for a reason. Its mechanism of action sets it apart from traditional pain-relief approaches. Unlike medications or other treatments that merely provide a “band-aid solution,” PRP therapy taps into your body’s natural healing power, tackling knee pain at its source and providing significant and lasting relief.

Here is how it works: your interventional pain management physician draws a small sample of your blood, spins it in a centrifuge to concentrate the platelets, and then injects the solution directly into your knee. Once there, the platelets release growth factors that promote tissue repair, reduce inflammation, and support healing at a cellular level.

Studies on PRP therapy have shown excellent outcomes, especially in people with early-stage osteoarthritis or chronic tendon injuries, making it a great choice for those seeking an effective and more sustainable solution to knee pain.

 

Radiofrequency Ablation: An Innovative Solution to Knee Pain

Radiofrequency ablation (RFA) is another option worth considering for those looking for a non-drug and nonsurgical approach to treating chronic knee pain.

Radiofrequency ablation (RFA) for knee pain involves delivering controlled heat generated from high-frequency radio waves through a specialized needle or thin catheter. The heat is aimed right at the nerves surrounding the knee to disrupt their ability to send pain signals to your brain. By heating and disrupting these nerves, RFA effectively “turns off” the pain pathway without affecting surrounding structures.

RFA not only stands out for its efficacy but also for its minimally invasive nature. Unlike surgery, RFA does not involve incisions or cutting through the skin. It requires only a tiny puncture, which means minimal discomfort, low risk of complications, and little to no downtime.

RFA does not fix the underlying condition, but it does provide real results that can last for several months, sometimes even up to a year or more. Mounting scientific evidence points to RFA’s effectiveness in relieving chronic knee pain.

 

Where to Get the Best Relief for Knee Pain in Melbourne, FL

If you have been stuck in the pain medication merry-go-round or told that surgery is your only option for knee pain, reach out to our experts.

Here at Central Florida Spine & Pain, we specialize in helping people conquer pain and get back to living their best lives without relying on pain medications or resorting to drastic measures like surgery. We offer a wide range of interventional pain management services, including viscosupplementation, radiofrequency ablation, and PRP therapy, all of which are minimally invasive and have been clinically proven to provide significant relief.

Take the first step toward a pain-free life by scheduling an appointment with us today. Reach out to us at (321) 802-5021.

 

 

External Sources:

  • https://www.ncbi.nlm.nih.gov/books/NBK598215/
  • https://www.hopkinsmedicine.org/health/conditions-and-diseases/arthritis/viscosupplementation-treatment-for-arthritis#:~:text=What%20is%20viscosupplementation%20treatment%20for,of%20cartilage%20on%20their%20ends.
  • https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/plateletrich-plasma-prp-treatment
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC11563554/

 

Filed Under: knee pain Tagged With: best pain relief for knee pain, Best Relief for Knee Pain in Melbourne FL, interventional pain management services, knee gel injections, minimally invasive, non-drug and nonsurgical approach, Osteoarthritis, PRP Therapy, Radiofrequency Ablation, viscosupplementation

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At Central Florida Spine & Pain,  Dr. Giordano offers Interventional Pain Therapies and Minimally Invasive Treatments for acute and chronic pain conditions.